Artificial Intelligence analytics toolkit for predicting Virus mutation in protEin (AIVE) is a Web and GPU based analysis tool that can predict protein structures and properties from user-entered viral sequences. AIVE uses AlphaFold2 software (https://github.com/deepmind/alphafold) to evaluate protein structures. AIVE provides independently developed mathematical models (SCPS, PCS, MR, BPES, APESS). It provides information on structural differences (SCPS, PCS), physical changes (MR), and biochemical changes (BPES) at the amino acid and nucleotide levels. These tools were calculated using various information such as amino acid chemical properties (pH, Hydrophobic, Residue), molecular structure prediction results (PAE, pLDDT), mutation and codon frequencies in viruses, and amino acid polarity features. AIVE serves optimized analysis and prediction for SARS-CoV-2 viral mutations. Analysis and prediction of other virus species will be updated later.